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Rustgis team wondered if similar enzymes in natural heat lovers might provide some clues into the structural features that impart temperature stability

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Nrf2 augments expression of the cysteine uptake transporter EAAT3 (excitatory amino acid transporter 3) and the cystine-glutamate antiporter xCT, as well as transsulfuration pathway enzymes cystathionine beta synthase (CBS) and cystathionine gamma lyase, also known as cystathionase (CSE) [108,109,110,111]